Page 24 - Dr Alessandra NIVOLI
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Quetiapine dans la dépression bipolaire
Pointage total de la MADRS sur 8 semaines de baseline (ITT, LOCF)
Study week Study week
0 1 2 3 4 5 6 7 8 0 1 2 3 4 5 6 7 8
0
Quetiapine 600 mg/day
-5 Quetiapine 300 mg/day
Placebo
-10 *** ***
Improvement -15 *** *** *** *** *** *** *** ***
-20 *** *** *** *** *** ***
BOLDER I BOLDER II
(n=511) (n=467)
***p<0.001 vs placebo for both active arms
at all timepoints Calabrese et al 2005; Thase et al 2006
