Page 4 - Dr. Elie Hantouche
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Activation Syndrom linked with
Antidepressants
◼ Activation syndrome (AS) = cluster of symptoms
listed by the US FAD as possible suicidality
precursor during antidepressant treatment.
◼ AS Rate = 52.2% of BP-II/BP-NOS vs 13.5% of
MDD, (p<0.01).
◼ Factors linked with AS (Univariate analysis):
◼ BP-II/BP-NOS diagnosis
◼ Cyclothymic temperament
◼ Early age at onset of first MDE
◼ Psychiatric comorbidities
◼ Depressive mixed state (DMX)
Takeshima & Oka, J Affect Disord. 2013 Oct;151(1):196-202.
Antidepressants
◼ Activation syndrome (AS) = cluster of symptoms
listed by the US FAD as possible suicidality
precursor during antidepressant treatment.
◼ AS Rate = 52.2% of BP-II/BP-NOS vs 13.5% of
MDD, (p<0.01).
◼ Factors linked with AS (Univariate analysis):
◼ BP-II/BP-NOS diagnosis
◼ Cyclothymic temperament
◼ Early age at onset of first MDE
◼ Psychiatric comorbidities
◼ Depressive mixed state (DMX)
Takeshima & Oka, J Affect Disord. 2013 Oct;151(1):196-202.
