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Treatment implications of mixed mania
• Lithium resistance
• Anticonvulsants
– Valproate
• Atypical antipsychotics with “antidepressant”
properties
– Quetiapine, Asenapine, Olanzapine
• Other strategies
– Drug combination
– ECT
Bowden. J Clin Psychiatry 1995;56 Suppl 3:25–30;
Vieta. Eur Psychiatry 2005;20(2):96–100;
Szegedi et al. BMC Psychiatry 2011;11:101;
Perugi et al. Brain Stimul 2012;5(1):18–24
