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Worsening OCD by Antidepressants:
The Role of Affective Temperaments
OCD Worsened OCD not
by AD Worsened by AD p
(n = 52) (n = 222)
Cyclothymic 65% 50% .06
Temperament 11,5 9,4 .01
Irritable 34% 14% .007
Temperament 6,9 5,1 .009
Suicide attempts 31% 18% .04
French study in a sample of 360 patients with OCD
Hantouche et Demonfaucon, Encephale, 2008
