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Specificity of Mixed Depressions versus
Pure Depressions in Bipolar Disorder
• Early onset
• Suicide risk
• More exposure to antidepressants
• Psychotic features
• Chronic course (more time in illness)
• Recurrent depression
• Rapid cycling
• Mood switching
Goldberg et al, 2009; Valenti et al, 2011, Azorin et al, 2012.