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Tufts-Duke RCT: Ziprasidone in
Mixed Depression
Ziprasidone vs Placebo: 6 week change in
MADRS from baseline
• N= 74
0 Placebo (N=38)
• 6 week double-blind Ziprasidone (N=35)
-2
placebo controlled
-4
• mean dose 122.4 mg/d -6
(LOCF) Mean Change MADRS from baseline -8
-10 ***
* P < 0.05 vsplacebo
*
-12 ***p <0.001 vsplacebo
*
-14
A Patkar,, PLoS One, April 2012
