Page 61 - PowerPoint Presentation

Pathoplastic effect of

cyclothymia on episodes

Hypomania Depression

 Increased global  Earlier age of onset

severity  Increased global severity

 “Dark” side  Higher frequency of guilt,

(irritability, risk PM agitation, suicide

taking, substance thoughts

abuse…)

 Mixed hypomania  Higher recurrence

 Higher recurrence  Suicidal behaviors

 Shorter delay to switch

under AD

Hantouche et al, JAD 2003; Akiskal et al JAD 2006