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Bipolar risk factors by diagnostic
algorithm (Analysis population)
• Logistic regression
FACTOR ODDS RATIOS
Bipolar HLC32- Known
DSM-IV mDSM-IV disorder
R2
bipolar
(n=5027) (n=5014) specifier (n=4877) (n=5022)
(n=5027)
Hypomania/mania among first degree relatives 2.17 2.43 3.84 2.36 2.82
Age of first psychiatric symptoms <30 years 1.54 1.44 1.68 1.81 1.59
Total number of mood episodes in the past ≥2 2.62 2.85 2.11 1.35 7.40
Previous response to antidepressants: 0.58 4.88 9.51 3.40 4.62
manic/hypomanic switches
Previous response to antidepressants: mood 1.51 1.95 1.98 1.25 1.81
lability
Current depressive symptoms: concomitant 1.35 1.390 2.17 1.53 1.13
mixed state during depression (1)
Substance abuse (alcohol or other) 0.84 1.99 2.17 2.07 1.35
(1) Mixed state = 2 of the following: racing thoughts, mixed state, more talkative, distractibility
(2) Atypical depression = 2 of the following: hypersomnia, hyperphagia, leaden paralysis
Grey cases refer to significant odds ratio
